The rearranged match, which was postponed in December due to adverse weather conditions, is due to kick off at 19:30 GMT.
Here are 22 facts and figures you need to know ahead of the 245th official meeting between the Reds and the Blues...
This match is Liverpool's 122nd and final visit to Goodison Park, including two FA Cup semi-finals.
It will be the last game of a season in which the first derby of a campaign is played. The last was in 2005, when the Reds won 3-1 at Goodison on December 28.
Liverpool have won 99 games against Everton in all competitions (D77, L68). If the Reds win on Wednesday, it will be only the fifth time that an English league team has beaten another in 100 games since the Football League was founded in 1888 (Arsenal 111 v Everton, Manchester United 106 v Aston Villa, Liverpool 103 v Aston Villa and Arsenal 100 v Manchester City).
To date, the clubs have each won 41 times in their meetings at the Blues' current home, with 37 draws.
Liverpool have lost just two of their last 27 Premier League games against Everton (W12, D13), with those defeats coming in February 2021 (2-0 at Anfield) and April 2024 (2-0 at Goodison Park).
Everton-Liverpool is the match with the most red cards (23) and the most 0-0 draw (12) in the history of the Premier League.
Liverpool have scored more 90-minute winners against Everton in the competition than any other team against a single opponent (five).
Everton last won consecutive Merseyside League derbies in the 1984–85 campaign.
Liverpool's defeat in this game last season ended a 12-match unbeaten run in the Premier League against Everton (W3, D9). They have not lost consecutive visits to Goodison Park since a run of three between
1992 and 1994.
The Reds are unbeaten in their last 19 Premier League games (W14, D5). On both previous occasions they played an away league game against Everton with an unbeaten run of over 19 games but lost (1-0 in October 1978 with a run of 23 games and 1-0 in March 1988 with a run of 19 games).
of 31 matches).
This is Arne Slot's first meeting with Everton as Liverpool manager. Only one Reds manager has won his first league derby on Merseyside after that away game, with Kenny Dalglish overseeing
the 3-2 victory in September 1985.
The Reds are the only team in the top four divisions of English football to remain unbeaten away from home this season (played 12, won nine and drew three). Only in 1987-88 (15) and 2019-20 (13) have they enjoyed a longer unbeaten run on the road since the start of a top-flight campaign.
Liverpool are top of the Premier League for goals (56), xG (54.7), shots (411), shots on target (159) and big chances (100) this season. They have also spent 47 per cent of their games in the lead, the highest percentage of any team in the division this season.
This is only the third time in the Premier League that Liverpool have faced Everton while top of the table at the start of the day. The others were a 5-2 win and a 0-0 draw in 2019-20, with the Reds going on to win the title that season.
David Moyes won three of his 22 Premier League Merseyside derbies in charge of Everton between 2002 and 2013 (d7, l12). This is his first game against Liverpool as Toffees boss since a goalless draw at Anfield in May.
of 2013.
Moyes will take charge of a game against Liverpool for the 43rd time in his career. Only seven men have faced the Reds
more frequently.
Everton have won their last three Premier League games by an aggregate score of 8-2 - that's as many wins as they had in their previous 21 league games and as many goals as they had scored in their previous 14.
Only Liverpool and Nottingham Forest (10 each) have kept more clean sheets in the Premier League than Everton this season (nine), with the Toffees goalless in each of their last two games.
Mohamed Salah has been directly involved in 21 goals in Liverpool's 12 Premier League away games this season (13 goals, eight assists). It is the most goals scored by a player away from home in a single campaign in the competition's history, level with Andrew Cole in 1993-94 (12 goals).
, nine assists).
Ryan Gravenberch could make his 50th league appearance for the Reds.
Luis Díaz could play his 100th game for Liverpool in all competitions.
Alisson Becker has kept a clean sheet in seven games against Everton, all in the league.
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