Egypt's Mohamed Salah, who scored a hat-trick on last season's visit to Old Trafford, is currently tied with Steven Gerrard (nine) for goals against the Reds' arch-rivals in the derbies.
A goal in Monday 22 August's game would also make Salah only the second Liverpool player in history to score in four successive league games for United - the other being Dick Forshaw in 1925-26 and again in 1926-27.
Alisson Becker will also break another record, as it will see him enter the club's all-time top 10 goalkeepers list. Fabinho could make his 100th Premier League appearance.
Salah (119) is third on the list of most Premier League goals for Liverpool behind Robbie Fowler (128) and Steven Gerrard (120, while the Reds are four goals away from recording 800 in all competitions under Jürgen Klopp.
German manager Jurgen Klopp's side could become the first in the club's history to win on three consecutive visits to Old Trafford in the league. They could also make it five league games unbeaten at Old Trafford for the first time since 1927 and equal the club record. Liverpool have scored in 29 of their last 30 away league games, with the exception of a 1-0 defeat at Leicester City last December.
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